# Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA)

Notice 25b718f2257845f3880f6a7f41f9e5df (solicitation ARPA-H-SOL-26-163) from HEALTH AND HUMAN SERVICES, DEPARTMENT OF, ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H), posted 2026-11-09, responses due 2026-12-02T20:00:00.000Z. Status: open.

| Field | Value |
| --- | --- |
| Notice ID | 25b718f2257845f3880f6a7f41f9e5df |
| Solicitation number | ARPA-H-SOL-26-163 |
| Type | Solicitation |
| Agency | HEALTH AND HUMAN SERVICES, DEPARTMENT OF |
| Sub-tier | NATIONAL INSTITUTES OF HEALTH |
| Office | ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H) |
| Posted | 2026-11-09T16:53:28.000Z |
| Response deadline (UTC) | 2026-12-02T20:00:00.000Z |
| Set-aside | - |
| NAICS | 541715 |
| PSC | AN13 |
| Place of performance | USA |
| Award | - |

## Description

Amendment 3 (11/09/2026): ISO updates to Part II - Technical Areas & Requirements: TA1: Edits to the "Target" language for the Retrospective Data Access metric. Amendment 2 (10/29/2026): Numerous changes including, but not limited to,: ISO updates in Parts I, II, III and VI; TA1 clarifications; TA2 updates; TA4 updates; Q&A link added Provides Attachment B1 for TA4 Proposal Requirements and Proposal Volume Templates. Provides Attachment A2 for TA1 Solution Summary Requirements and Attachment A3 for TA2 Solution Summary Requirements. Amendment 1 (10/14/2026): Update due dates and/or times of all TAs SPECTRA will identify and act on autism trajectories, the evolving developmental paths individuals follow across the lifespan from the prenatal period through aging, spanning autism characteristics, co-occurring conditions, and functional outcomes together with the genetic, biological, behavioral, iatrogenic (medical influences), environmental factors and their nonlinear interactions. Rather than examining these factors in isolation, SPECTRA will examine how they combine and interact, including their nonlinear interactions, to produce autism and its co-occurring conditions over time. SPECTRA will also develop technologies that serve two purposes at once: extending reliable assessment beyond the clinic while improving everyday communication, function, and quality of life. The same tools people use to live more fully will also generate the data that drive measurement and personalized care.

## Sources

- View on SAM.gov: https://sam.gov/opp/25b718f2257845f3880f6a7f41f9e5df/view
- Data as of 2026-11-14. Source: https://sam.gov/data-services/Contract%20Opportunities/datagov

## Cite this

"Systems for Phenotypic Evaluation, Clinical Trajectories, Response, and Agency (SPECTRA), SAM.gov contract opportunity 25b718f2257845f3880f6a7f41f9e5df." samgovapi.io, https://samgovapi.io/opportunity/25b718f2257845f3880f6a7f41f9e5df, data as of 2026-11-14. Primary record: https://sam.gov/opp/25b718f2257845f3880f6a7f41f9e5df/view

## API and MCP

- REST: GET https://samgovapi.io/api/v1/opportunities/25b718f2257845f3880f6a7f41f9e5df
- MCP tool: get_opportunity

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