# High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Notice 7cc49984be44476e8798ab0e0c1f253b (solicitation DARPA-PA-27-01) from DEPT OF DEFENSE, DEF ADVANCED RESEARCH PROJECTS AGCY, posted 2026-10-28, responses due 2026-11-05T20:00:00.000Z. Status: open.

| Field | Value |
| --- | --- |
| Notice ID | 7cc49984be44476e8798ab0e0c1f253b |
| Solicitation number | DARPA-PA-27-01 |
| Type | Solicitation |
| Agency | DEPT OF DEFENSE |
| Sub-tier | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY  (DARPA) |
| Office | DEF ADVANCED RESEARCH PROJECTS AGCY |
| Posted | 2026-10-28T15:37:29.000Z |
| Response deadline (UTC) | 2026-11-05T20:00:00.000Z |
| Set-aside | - |
| NAICS | 541714 |
| PSC | AC12 |
| Place of performance | - |
| Award | - |

## Description

UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

## Sources

- View on SAM.gov: https://sam.gov/opp/7cc49984be44476e8798ab0e0c1f253b/view
- Data as of 2026-11-14. Source: https://sam.gov/data-services/Contract%20Opportunities/datagov

## Cite this

"High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE), SAM.gov contract opportunity 7cc49984be44476e8798ab0e0c1f253b." samgovapi.io, https://samgovapi.io/opportunity/7cc49984be44476e8798ab0e0c1f253b, data as of 2026-11-14. Primary record: https://sam.gov/opp/7cc49984be44476e8798ab0e0c1f253b/view

## API and MCP

- REST: GET https://samgovapi.io/api/v1/opportunities/7cc49984be44476e8798ab0e0c1f253b
- MCP tool: get_opportunity

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