# Protein ENGineering (PENG)

Notice be313c6423e841ae9572a0878b3d9bbb (solicitation DARPA-PS-26-129) from DEPT OF DEFENSE, DEF ADVANCED RESEARCH PROJECTS AGCY, posted 2026-08-07, responses due 2026-10-19T20:00:00.000Z. Status: open.

| Field | Value |
| --- | --- |
| Notice ID | be313c6423e841ae9572a0878b3d9bbb |
| Solicitation number | DARPA-PS-26-129 |
| Type | Solicitation |
| Agency | DEPT OF DEFENSE |
| Sub-tier | DEFENSE ADVANCED RESEARCH PROJECTS AGENCY  (DARPA) |
| Office | DEF ADVANCED RESEARCH PROJECTS AGCY |
| Posted | 2026-08-07T15:37:55.000Z |
| Response deadline (UTC) | 2026-10-19T20:00:00.000Z |
| Set-aside | - |
| NAICS | 541714 |
| PSC | AC12 |
| Place of performance | - |
| Award | - |

## Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

## Sources

- View on SAM.gov: https://sam.gov/opp/be313c6423e841ae9572a0878b3d9bbb/view
- Data as of 2026-11-14. Source: https://sam.gov/data-services/Contract%20Opportunities/datagov

## Cite this

"Protein ENGineering (PENG), SAM.gov contract opportunity be313c6423e841ae9572a0878b3d9bbb." samgovapi.io, https://samgovapi.io/opportunity/be313c6423e841ae9572a0878b3d9bbb, data as of 2026-11-14. Primary record: https://sam.gov/opp/be313c6423e841ae9572a0878b3d9bbb/view

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